Information about Quatrefolic®

Folate – a critical nutrient prior to conception

Quatrefolic Folate is one of the most important nutrients before and during pregnancy.
  • Folate is a B vitamin found naturally in foods, especially leafy green vegetables, dried beans and peas, and citrus fruits and juices.
  • Folate helps your baby’s brain and spinal cord develop properly and is especially important early in pregnancy.
  • May not be consumed in adequate amounts from food to ensure proper development of your baby’s nervous system.
  • Folate is a nutrient so vital that a synthetic (man-made) form called folic acid is added to foods.

Quatrefolic® – The fourth generation folate

The generations of folate:

Chronology: The generations of folate

1st Generation – Food Folate

Refers to the various tetrahydrofolate derivatives naturally present in foods.

2nd Generation – Folic Acid

Folic acid is a synthetic oxidized molecule that does not occur naturally in nature. It can, however, be used by the human body as a precursor to form natural folates that are biologically active. Folic acid lacks coenzyme activity and must be reduced to the metabolically active form within the cell before it can be used by the body’s cells in metabolic pathways such as DNA production, cell reproduction and homocysteine metabolism.

3rd Generation – (6S)-5-methyltetrahydrofolate calcium salt

The calcium salt of 5-methyltetrahydrofolate is available commercially and is able to penetrate the body cells without needing further metabolism.

4th Generation – Quatrefolic®

Quatrefolic® is a new generation of folate derivative, (6S)-5-methyltetrahydrofolate glucosamine salt.

The Quatrefolic® Advantage

  • Up to 50% of women have an impaired ability to convert folic acid into active folate.
  • Quatrefolic does not need further metabolism and can penetrate cells as is.
  • This folate is endowed with long lasting stability as well as peculiarly high water solubility, improved bioavailability and well established safety.

Mechanism of Action

The mechanism of action of Quatrefolic® is related to the action of 5-methyltetrahydrofolate the active part of the proprietary ingredient.

5-methyltetrahydrofolate derives from tetrahydrofolic acid, through a series of metabolic reactions. Tetrahydrofolic acid acts as a coenzyme in several vital metabolic reactions participating in the transfer as acceptors and donors of various one-carbon fragments, involved in the biosynthesis of nucleotides purines and pyrimidines and in the metabolism of several important amino acids.

In concert with vitamin B12, folate coenzymes allow the conversion of the amino acid homocysteine to methionine, the lack of this conversion has been associated with various pathologies and diseases.

Conversion of tetrahydrofolic acid to 5-methyltetrahydrofolate is mediated by the action of the enzyme methylentetrahydrofolate reductase. In individuals with a genetic defect of methylentetrahydrofolate reductase enzyme conversion is limited, predisposing these individuals for an increased risk for certain disease conditions.

Supplementation with 5-methyltetrahydrofolate might be preferable to folic acid, being it is immediately available to react with homocysteine to avoid the possibility of hyperhomocysteineamia.

Main Components of the Folate Biochemical Cycle. Abbreviations: DHFR = dihydrofolate reductase; MTHFR = methylenetetrahydrofolate reductase.


Pathway 1:
Biosynthesis of nucleotides for incorporation into DNA and RNA;

Pathway 2:
Remethylation of homocysteine to form methionine (vitamin B12 serves as a coenzyme in this reaction);
3 - Methylation of substrates, including DNA, RNA, phospholipids, and proteins;
4 - MTHFR, which catalyzes the formation of 5-methylfolate needed for methylation reactions;
5 - Dihydrofolate reductase enzyme.
WARNING: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose, call a doctor or poison control center immediately.
WARNING: Ingestion of more than 3 grams of omega-3 fatty acids (such as DHA) per day has been shown to have potential antithrombotic effects, including an increased bleeding time and International Normalized Ratio (INR). Administration of omega-3 fatty acids should be avoided in patients taking anticoagulants and in those known to have an inherited or acquired predisposition to bleeding.
Quatrefolic® is a registered trademark of Gnosis, SpA.
Covered by one or more claims of U.S. Patent # 7,947,662 CAS# 1181972-37-1
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